Omeprazole has active ingredients of omeprazole. Diarrhea, a headache, drowsiness, abdominal pain, nausea or vomiting, or tongue discoloration. Omeprazole takes around 1 hour to block the production of stomach acid, and its maximal effect occurs around 2 hours after taking the pill. Location. A slow increase of dose may improve gastrointestinal tolerability. To help relieve this pain, antacids may be taken with omeprazole, unless your doctor tells you otherwise. Some studies report that PPIs may increase the risk of bone fractures. * Approximation only. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. In these cases, splitting the dose and giving a PPI twice daily, before breakfast and dinner, provides superior intragastric pH control, particularly at night, when compared to a double dose given once daily. privacy practices. A Pharmaceutical Rep Tells Me That PPIs Often Fail Because Patients Do Not Take Them as Directed. Note that this list is not all-inclusive and includes only common medications that may interact with omeprazole. The Food and Drug Administration (FDA) have approved omeprazole capsules and granules for the following medical conditions: People can use OTC omeprazole tablets to treat frequent heartburn that occurs two or more times per week. Some studies have suggested PPIs (such as omeprazole) are associated with a higher risk of stomach cancer and kidney disease. The presence of other medical problems may affect the use of this medicine. People taking omeprazole for long periods of time may become deficient in some vitamins and minerals, including vitamin B-12 and magnesium. 2023 eHealthMe.com. They may also suggest a different PPI. You may need to stop using this medicine several days before you have medical tests. A combination of famotidine and omeprazole raised the gastric pH level to >4 in less than 1 h. The percentage of daytime with pH > 4 on day 1 was significantly higher with the combination of omeprazole and famotidine (median: 37%) than that with omeprazole alone (22%; p < 0.05). The amount of medicine that you take depends on the strength of the medicine. All rights reserved. (Reprinted from Hatlebakk JG, Katz PO, Kuo B, Castell DO. 3. Chronic acid reflux may be diagnosed as gastroesophageal reflux disease, or GERD. If any medicine remains after drinking, add more water, stir, and drink immediately. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. It belongs to a group of medicines known as proton pump inhibitors (PPIs). stomach pain. Take omeprazole powder for oral suspension on an empty stomach at least 1 hour before a meal. Adults20 milligrams (mg) once a day for 4 to 8 weeks. Compared with treatment with omeprazole alone, on day 1 famotidine and omeprazole in combination improved the duration of and time to reach intragastric pH > 4. Conclusions: Effect of Helicobacter pylori status on intragastric pH during administration of lafutidine or famotidine. Available for Android and iOS devices. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. If your dose is different, do not change it unless your doctor tells you to do so. If your healthcare provider recommends omeprazole, it's best to take it every day. These medications are not usually taken together. nausea, vomiting, diarrhea, gas, or. In patients with nighttime symptoms, an evening dose before dinner may be effective. Would you like email updates of new search results? Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Omeprazole. (n.d.). Along with its needed effects, a medicine may cause some unwanted effects. Expert's Assistant chat. Omeprazole is also used to treat Zollinger-Ellison syndrome, a condition where the stomach produces too much acid. Before To treat erosive esophagitis caused by acid-mediated GERD: Adults and children 17 years of age and older20 milligrams (mg) once a day before a meal. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Empty the contents of a 2.5 milligrams (mg) packet of powder into a container containing 5 mL of water. Nocturnal gastric acidity and acid breakthrough on different regimens of omeprazole 40 mg daily. Dr. Glatter warns that CoQ10 can also lower blood sugar, and if you are taking other diabetes drugs, you run the risk of developing low blood sugar, he says. Your doctor may adjust your dose as needed. Intragastric 24-h pH-metry was performed in healthy, Helicobacter pylori-negative volunteers on day 1 and after 8 days of daily administration of 20 mg omeprazole, 10 mg famotidine, or a combination of these in a three-way crossover design. Call your doctor for medical advice about side effects. Aspirin and omeprazole should not be used to treat a sudden onset of heart attack or stroke symptoms (chest pain, sudden numbness or weakness, slurred speech). Advertising revenue supports our not-for-profit mission. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Do not double doses. 2007 Jun;54(76):1280-4. For a full list, see the leaflet inside your medicine packet. Topical exposure to Cerenia (maropitant citrate) may elicit localized skin reactions in some individuals. Copyright: Merative US L.P. 1973, 2023. Just because something is natural doesnt mean it is risk-free. Garlic isnt the only supplement that can up your bleeding risk. Next, be sure to check out these vitamin mistakes you might not know youre making. Omega-3 fish oil supplements may tame inflammation and improve your mood, but when you take these supplements with herbs that thin the bloodsuch as ginkgo biloba or garlicthey may prevent clotting and can lead to uncontrolled bleeding, Dr. Cooperman says. Keep from freezing. If any medicine remains after drinking, add more water, stir, and drink immediately. Make sure you tell your doctor if you have any other medical problems, especially: Take this medicine only as directed by your doctor. famotidine 10 mg (Pepcid AC) b.d. The drug Cerenia is the first and the only FDA-approved medication for veterinarians to offer cats and dogs to prevent acute vomiting and nausea as a prescription. Bethesda, MD 20894, Web Policies Ask your doctor if you have any questions. The Cerenia is not quick acting so it needs to be taken on a regular or routine basis. Other drugs that have the same active ingredients (e.g. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. When used together, it can increase the effects of Abilify in the body by increasing its blood levels. Omeprazole reduces the production of stomach acid and works by irreversibly blocking the actions of an enzyme responsible for acid production, called H+/K+ ATPase (also known as the gastric proton pump). To treat erosive esophagitis caused by acid-mediated GERD: Adults and children 17 years of age and older20 milligrams (mg) once a day before a meal. This is more likely to occur if you are taking this medicine for more than 1 year, or if you are taking this medicine together with digoxin (Lanoxin) or certain diuretics or "water pills". eHealthMe is studying from 360,065 Omeprazole users for its effectiveness, alternative drugs and more. Can cerenia, mirtazapine and pepcid be given together to a dog with nausea from liver cancer and kidney failure? Is It True That Some PPIs Need to Be Given Before Meals, but Others Do Not? Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Mayo Clinic does not endorse companies or products. information and will only use or disclose that information as set forth in our notice of Some medicines and omeprazole can affect each other and make it more likely that you'll have side effects or stop one of the medicines working properly. Tell your doctor if you're taking these medicines before you start omeprazole treatment: These are not all the medicines that may not mix well with omeprazole. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Serious stomach conditions may occur while taking this medicine alone or together with antibiotics. I've been doing this for weeks now and I don't see any bad reaction, but I . Do not heat, chew, or store the applesauce for later. PPIs (omeprazole, lansoprazole, esomeprazole, pantoprazole, and others) help reduce the amount of stomach acid made by glands in the lining of . Cetirizine hydrochloride has active ingredients of cetirizine hydrochloride. Usually, once a day oral powder, tablet or capsule, that can be administered with food. Cerenia is usually given to cats in the injectable form a dose of 1 mg/kg body weight (1 ml/10 kg body weight) as a subcutaneously administered injection, but it can also be given as an intravenous injection. Nocturnal gastric acidity and acid breakthrough on different regimens of omeprazole 40 mg daily. Omeprazole is available as a tablet and capsule formulation in various strengths and also as an oral suspension. The phase IV clinical study analyzes what interactions people who take Cetirizine hydrochloride and Omeprazole have. Some researchers have linked PPIs, including omeprazole, to Clostridium difficile diarrhea. For oral dosage forms (capsules, delayed-release capsules or suspension, or tablets): Adults20 milligrams (mg) once a day before a meal. Talk to your doctor if you have concerns. Aliment Pharmacol Ther. The following information includes only the average doses of this medicine. Some doctors have reported higher methotrexate levels in people taking high dose methotrexate with omeprazole. PPIs (including omeprazole) have been associated with an increased risk of osteoporosis-related fractures of the hip, wrist, or spine. Omeprazole - Uses, Side Effects, and More Uses Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). A pharmacist can also make one. Please enable it to take advantage of the complete set of features! Fluid Therapy. The amount of medicine that you take depends on the strength of the medicine. We study millions of patients and 5,000 more each day. The level of magnesium in your blood is more likely to fall too low if you take omeprazole with . World J Gastrointest Pharmacol Ther. Although not all of these side effects may occur, if they do occur they may need medical attention. Omeprazole is used to treat certain conditions where there is too much acid in the stomach. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Drug information provided by: Merative, Micromedex. Schizophrenia: Researchers say network disruptions in the brain may be a factor, Schizophrenia: How blood vessel growth in the brain may be a factor, Why adults in rural areas face higher risk of heart failure, Home remedies and lifestyle tips for reducing acid reflux. Some reports may have incomplete information. Federal government websites often end in .gov or .mil. They're generally not tested for the effect they have on other medicines. Omeprazole may interfere with the action of some antiretroviral drugs. Ask your healthcare professional how you should dispose of any medicine you do not use. Using alcohol or tobacco with certain medicines may also cause interactions to occur. If you take a multivitamin dont worry, but if you are K deficient and need extra K, take it two hours apart from the other fat-soluble vitamins, he says. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of omeprazole in the elderly. Do not crush, break, or chew the capsule or the tablet. Swallow the capsule and tablet forms of omeprazole whole. By reducing the acidity of the stomach contents, omeprazole may interfere with the following drugs: Existing research does not demonstrate that omeprazole is harmful during pregnancy. information is beneficial, we may combine your email and website usage information with Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. SELECTED NEPHROTOXIC AGENTS/BACITRACIN ACE. But if you mix it with green tea, black tea, or curcumin supplements, your body wont absorb the mineral. Administration of PPIs (such as omeprazole) has been associated with acute interstitial nephritis, a severe inflammation of the kidneys. 2014 May 6;5(2):57-62. doi: 10.4292/wjgpt.v5.i2.57. Customer: . Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. It is often used in gastroesophageal reflux disease. The study uses data from the FDA. If you are one of the 95 million Americans with high cholesterol, you might like the idea of taking a natural supplement to lower your levels. For oral dosage form (powder for suspension): To prevent upper gastrointestinal tract bleeding in seriously ill patients: AdultsThe first day: 40 milligrams (mg) for the first dose, then after 6 to 8 hours, a second 40 mg dose. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Researchers have not conducted studies on the efficacy of omeprazole past 12 months. You can learn more about how we ensure our content is accurate and current by reading our. information highlighted below and resubmit the form. Dosage: Depends on the source. There have also been reports of false-positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving PPIs, such as omeprazole. May be used in addition to antibiotics to eradicate. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun. This content does not have an English version. If you notice any other effects, check with your healthcare professional. Take omeprazole capsules or delayed-release capsules before a meal, preferably in the morning. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. The dose is usually taken together with clarithromycin or clarithromycin plus amoxicillin. Researchers have found limited evidence to suggest that omeprazole is present in breast milk. Results: . 2023 Healthline Media UK Ltd, Brighton, UK. Symptoms include fever, rash and generalized aches and pains. This can happen out of the blue, often after you have been taking CoQ10 for six to eight weeks, and it could precipitate a fall or head injury. Watch out for these other symptoms of low blood pressure. The recommended dosage of metoclopramide for dogs varies depending on the reason for treatment. Four-day continuous gastric pH monitoring following anti-acid secretory drug administration: cross-over test to assess the early effects. Dont miss these signs your body is running low on key vitamins. Do not take St John's wort, the herbal remedy for depression, while you're taking omeprazole. Using this medicine with any of the following medicines is not recommended. This is more likely if you are receiving this medicine for more than 1 year. In essence, the minerals compete with one another and both lose out. Omeprazole tablets may be taken with food or on an empty stomach. CoQ10 can also lower blood pressure. Dogs are typically dosed between 0.2 to 0.5 milligrams per kilogram of body mass every 8 hours. Immediate-release omeprazole at bedtime may be used in lieu of the evening dose a delayed-release PPI if nocturnal symptoms are not adequately relieved. There are no adequate or well-controlled studies of omeprazole during pregnancy but animal studies have shown changes in bone morphology in offspring of rats dosed throughout pregnancy and lactation. Take this medicine only as directed by your doctor. The medication is prescribed for use only once per day, typically to be administered before the actual start of the trip. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. health information, we will treat all of that information as protected health View complete list of side effects. PPIs such as omeprazole will block the release of acid, thus decreasing the acidity inside the stomach. If a higher dose is really needed, the patient should be treated with twice daily PPI, before breakfast and dinner. Ginkgo biloba, fish oil, ginger, feverfew, vitamin E, and white willow bark are also on the list. Omeprazole may also be used to maintain the healing of erosive esophagitis. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. If you miss a dose of this medicine, take it as soon as possible. Examples of these drugs include: Atazanavir, rilpivirine, and nelfinavir. include protected health information. Portions of this document last updated: April 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/omeprazole-oral-route/side-effects/DRG-20066836. After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. Your doctor may want you to take omeprazole for more than 8 weeks for certain conditions. The dose is usually 5 to 20 mg once a day before a meal. If someone needs long term treatment, doctors need to routinely monitor their vitamin B-12 and magnesium levels and suggest supplements as needed. These drugs are commonly used to treat gastroesophageal reflux disease (GERD), heartburn, and peptic ulcers. Be sure youre aware of niacin flush and what you can do about this potential side effect. Echinacea, a popular cold remedy, may decrease the effectiveness of blood thinners, and increase stroke risk, Dr. Glatter says. Conclusions: 2004 Jan;39(1):21-5. doi: 10.1007/s00535-003-1240-6. A new study has shed light on one of the long-term effects of proton pump inhibitors (PPIs). These side effects may go away during treatment as your body adjusts to the medicine. Do not use omeprazole if you are also using medicines containing rilpivirine (Edurant, Complera). In addition, omeprazole is used to prevent upper gastrointestinal tract bleeding in seriously ill patients. However, researchers have not consistently reported this effect. Adults60 milligrams (mg) once a day before a meal. Omeprazole basically acts as an antacid to reduce the production of stomach acid. Some doctors will detect kidney dysfunction in people taking omeprazole. Using omeprazole "as needed" isn't as effective as using it daily. All rights reserved. Read and follow these instructions carefully. Tell your doctor if you have Asian relatives, such as Filipino, Chinese, Japanese, Korean, or Taiwanese. The proton pump is located in the parietal cells of the stomach wall. There is a problem with Refill the syringe with an equal amount of water. the unsubscribe link in the e-mail. Drug interactions develop as a result of changes in the body's ability to absorb, metabolize, or excrete medications (among other, less common reasons), but the effects fall . It may take several days before this medicine begins to relieve stomach pain. It is safe to take painkillers such as paracetamol or ibuprofen at the same time as omeprazole. FDA approved, it's active ingredient is Maropitant citrate, which inhibits the activities of neurokinin-1 or NK1 receptors. Make sure you know thesuper-important questions to ask before you take prescription medications. Here are some more things to know if you are going to take melatonin. You need to be wary of over-the-counter or prescription drugs that can interact poorly with supplements, says Robert Glatter,MD, an assistant professor of emergency medicine at Northwell Health in New York City. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. We are no longer supporting IE (Internet Explorer) as we strive to provide site experiences for browsers that support new web standards and security practices. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. See your doctor if you develop any unexplained fever, rash (particularly one that gets worse after you have been in the sun), new or worsening joint pain, persistent diarrhea, or generalized aches and pains. You can easily overdo herbs or supplements with sedative properties. All available proton pump inhibitors (PPIs) are indicated for once-daily dosing, usually in the morning. This works to lower the amount of sugar in the blood of people with diabetes. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Iron and green tea. On day 1 treatment with both famotidine and the combination (famotidine and omeprazole) showed a significantly shorter time to reach a pH of 4 (medians: 93 and 63 min, respectively) compared with treatment with omeprazole alone (173 min; p < 0.05). Speak to your doctor about how drug interactions should be managed. Cerenia Dosage and Administration Cerenia Tablets are recommended for use in dogs 16 weeks and older. Adults20 milligrams (mg) once a day for 4 to 8 weeks. Common interactions include cough among females and infective pulmonary exacerbation of cystic fibrosis among males. Label: Prilosec OTC- omeprazole magnesium tablet, delayed release. Do not stop taking this medicine without first checking with your doctor, or unless told to do so by your doctor. In combination with blood pressure medications, this can cause dangerously low blood pressure, he says. Acid levels return to previous levels within 3 to 5 days of discontinuation. Copyright: Merative US L.P. 1973, 2023. Doctors prescribe omeprazole to children ages 116 based on their weight. Your doctor may adjust your dose as needed. All rights reserved. This includes prescription (eg, atazanavir, nelfinavir, Reyataz, Viracept) or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. Your doctor may adjust your dose as needed. You need iron to help distribute oxygen to cellsits vital for your energy. They may need more frequent blood testing to make sure that the dosage of warfarin is appropriate. Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness. Your doctor may want you to take omeprazole for more than 8 weeks for certain conditions. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness. For example, St. Johns wort may cause fever, confusion, and anxiety if its taken with other antidepressants. Omeprazole may greatly. Aliment Pharmacol Ther. In this article, we review the uses, side effects, and drug interactions of omeprazole. It is important that your doctor check your or your child's progress at regular visits. 2007 Jan 1;25(1):103-9. doi: 10.1111/j.1365-2036.2006.03129.x. Doctors must make an accurate diagnosis before prescribing omeprazole, as each diagnosis requires different treatments. Omeprazole is a proton pump inhibitor (PPI). Unauthorized use of these marks is strictly prohibited. This medicine is not approved for. A: Your friend is the victim of a double whammy. Do not keep outdated medicine or medicine no longer needed. Sometimes, vomiting is the problem in and of itself, and in these cases, the vomiting can be treated with Cerenia. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Omeprazole may be used to treat certain stomach conditions by decreasing levels of stomach acid. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. (2018). A recent study showed that acid-suppressing drugs such as omeprazole, lansoprazole (Prevacid) and esomeprazole (Nexium) also can lead to vitamin B-12 deficiency (JAMA, Dec. 11, 2013). This medicine may cause serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS). It may stop omeprazole working as well as it should. Swallow the capsule and tablet forms of omeprazole whole. eHealthMe is studying from 23,593 Cetirizine hydrochloride users for its effectiveness, alternative drugs and more. Shake the syringe and give the medicine through the nasogastric or gastric tube into the stomach with 30 minutes. https://www.mayoclinic.org/drugs-supplements/omeprazole-oral-route/side-effects/DRG-20066836, Advertising and sponsorship opportunities, Hypomagnesemia (low magnesium in the blood), history of or. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=61f67858-ba2f-449b-8b30-c15cdaf49222, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a1b077e6-b070-43f2-a98e-380cc635419d, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=35a79458-79f6-44d6-b74c-b4f4aaf0dde0, http://www.ncbi.nlm.nih.gov/books/NBK525994/, https://www.goodrx.com/prilosec?dosage=40mg&form=capsule&label_override=omeprazole&quantity=30%20, http://www.ncbi.nlm.nih.gov/books/NBK539786/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221858/. The https:// ensures that you are connecting to the atomoxetine Strattera Capsule Note: capsule contents can cause ocular irritation - Do not open capsules as contents are an ocular irritant benzonatate Tessalon Perles Capsule Note: swallow whole; local anesthesia of the oral mucosa; choking could occur - Capsules are liquid-filled "perles" - Do not alter (break, cut, chew) integrity Home remedies and lifestyle tips, Using a massage technique called myofascial release, researchers reduced the severity and frequency of acid reflux in a small group of people with, Heartburn is one symptom of the condition acid reflux. Cerenia Tablets For Cats Control in daytime pH was similar regardless of when a PPI is given; however, nocturnal pH control is significantly improved with the twice-daily regimen compared to double dose once daily (Figure 16-2). Figure 16-2. bisphosphonates, such as alendronate, etidronate, or risedronate, CYP2C19 inducers such as enzalutamide, rifampin, tocilizumab, or St John's Wort, CYP2C19 inhibitors such as amitriptyline, clomipramine, fluconazole or ticlopidine, HIV medications (eg, atazanavir, indinavir, ritonavir, or saquinavir), medications that rely on a certain gastric pH for absorption, such as ampicillin, bisacodyl, dasatinib, erlotinib, iron salts, ketoconazole/itraconazole, mycophenolate mofetil, or nilotinib, multivitamins that contain vitamins A, D, E, or K; folate; or iron, tumor necrosis factor inhibitors such as adalimumab, etanercept, or infliximab. Sustained daytime control may not be sufficient with IR-OME as a single dose at night. The applesauce should not be hot and should be soft enough to be swallowed without chewing. Delayed-release PPIs should not be given before bed on an empty stomach as they do not effectively control intragastric pH in the early part of the sleeping period when the majority of nighttime reflux occurs (see Questions 9 and 10). Tell your doctor if you are breastfeeding, pregnant, or intending to become pregnant because omeprazole may not be suitable for you. gefitinib. Proton pump inhibitors: better acid suppression when taken before a meal than without a meal. It is unknown how omeprazole affects a breastfeeding infant. Introduction Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of mortality and morbidity worldwide. Common interactions include depression among females and drug ineffective among males.