Additional studies to confirm safety and efficacy are needed. It appears to have some benefits for the treatment of menopause symptoms ( 26 ). Cultivating red-stalked rhubarb plants is an important source of raw materials for producing health-promoting foods. Now, I have one or two hot flashes at night and there was a time when I literally lost count. This article reviews the in vitro and in vivo data of its estrogenic actions, particularly those mediated by estrogen receptor- (ER). Phone: +91-712-2543006. Rhubarb has some mild . 4) Treats cold sores. Negative reviews mention no positive benefits and several adverse side effects. Therefore there is much interest in finding safe, alternative treatments for hot flashes and other symptoms caused by menopause. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Available for Android and iOS devices. A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(4):268-272. [Effects of baoshen pill in treating chronic renal failure with long- term hemodialysis]. We follow a strict editorial policy, especially related to the sources we use. Clinical observation on 40 patients with uremia treated by colonic dialysis with rhubarb. It includes rhaponticin and desoxyrhaponticin, which are able to stimulate estrogen receptors. Some medications that can harm the liver include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo). Jiao D, Shen X, Gao Y, and et al. Rhubarb is a plant. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Mild side effects of bloating and diarrhea were noted in the rhubarb group.56, In vitro studies and in vivo experiments in fish show that rhubarb extract possesses estrogenic activity, which has been suggested to be caused by the chemical lindleyin.10, R. officinale has been used in China to treat neonatal jaundice.43 In rats with induced cholestatic hepatitis, total bilirubin was decreased and the liver enzyme profile was improved with administration of emodin.44 A growth-promoting effect, resulting in liver regeneration, has been demonstrated by emodin.12, Other properties attributed to rhubarb include antiplatelet properties45 antihypertensive effects46 anti-inflammatory action47 and glucose homeostasis.48, Crude rhubarb extract 9 g powder was given daily to patients with sepsis.20 Rhubarb extract 20 mg/kg daily was administered for 6 weeks to patients undergoing radiation therapy.18 Patients with atherosclerosis were given rhubarb extract 50 mg/kg for 6 months.27, In Kampo medicine (the practice and adaptation of traditional Chinese medicine in Japan), long-term (12 months) use of rhubarb extract has been administered to improve Oketsu (blood stagnation), and short-term (2 weeks) use has been administered for lazy bowel syndrome.28, 49, Avoid dosages higher than those found in food because safety and efficacy are not proven. Iida, K., Hase, K., Shimomura, K., Sudo, S., Kadota, S., and Namba, T. Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale. A. Jiao, D. H. [Alcoholic extract tablet of rhubarb in treating acute upper gastrointestinal hemorrhage]. Pharmacology 1980;20 Suppl 1:128-30. Chung, K. T., Wong, T. Y., Wei, C. I., Huang, Y. W., and Lin, Y. Tannins and human health: a review. Another study showed that emodin inhibits human cancer cell invasiveness by specifically antagonizing the adenosine 5-triphosphate-gated Ca(2+)-permeable channel P2X7 receptor(17). Song, H., Wang, Z., and Zhang, F. [Investigation of urinary interleukin-6 level in chronic renal failure patients and the influence of Rheum palmatum in treating it]. View abstract. Quarterly Review of Natural Medicine 1997;unlisted:215. Kwan TH, Tong MK, Leung KT, et al. Nutrition Research 1998;18(5):893-903. Catechin, epicatechin, procyanidins, and gallylglucose were shown to inhibit hyaluronidase(10)(12). Last medically reviewed on December 23, 2021. Rhubarb, a perennial herb, is cultivated in many parts of the world and the stalks are sometimes consumed as food. If you already have kidney disease, don't risk making it worse by taking rhubarb. In fact, a supplement that contained rhubarb has been linked to one report of kidney failure. It claims to have been clinically demonstrated to relieve menopausal symptoms like hot flashes, sleep disturbances, irritability, anxiety, mood problems, exhaustion, and vaginal dryness. However, a person should speak with a doctor before taking either product. Lipid profiles were improved in the two experimental arms.22, Treating hypercholesterolemia in men with rhubarb stalk fiber for 4 weeks lowered serum total cholesterol and low-density lipoproteins (LDL), while high-density lipoproteins remained unchanged.26 In 103 patients with atherosclerosis randomized to receive the extract for 6 months, rhubarb extract improved the lipid profile in patients with chronic renal failure (CRF) compared with control.25 Individuals taking rhubarb reported decreased LDL compared with those taking placebo and compared with the pretreatment levels.27, The North American Menopause Society position statement for nonhormonal management of menopause-associated vasomotor symptoms (2015) states that although beneficial effects in overall symptoms have been reported with a commercial proprietary rhubarb extract preparation, more data are needed on both safety and efficacy of Siberian rhubarb (Rheum rhaponticum) for use in menopausal vasomotor symptoms (Level II).58, Large, randomized clinical trials are lacking. 1992;13(4):342-345. Learn more about menopause and insomnia. Protective effect of rhubarb combined with ulinastatin for patients with sepsis. Some of these medications that can harm the kidneys include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others. They contain substances called isoflavones, which are plant-based estrogens ("phytoestrogens"). Both brands claim that their products provide numerous benefits: Amberen claims that their Multi-Symptom Menopause Relief product relieves 12 symptoms, including: The supplements come as capsules and help restore hormone balance. Estroven should not be taken without guidance from a healthcare provider. Anthraquinone extracts of rhubarb induced cytotoxicity in cancer cell lines(5) and tumor necrosis in mice(1), although this has not been demonstrated in humans. Menofit is a probiotic supplement. Similarly to lipid-lowering properties of rhapontic rhubarb, also R. rhabarbarum showed a cardioprotective potential. I was in full swing menopause and I was pretty miserable. Rhubarb is also used as a flavoring agent. 1996;16(11):649-651. [1] Vollmer G, Papke A, Zierau O. Rhubarb is used primarily for digestive complaints including constipation, diarrhea, heartburn, stomach pain, gastrointestinal (GI) bleeding, and preparation for certain GI diagnostic procedures. Traditional Chinese medicine suggests rhubarb improves the memory in senile patients.37 In in vitro experiments, rhapontigenin exerted a dose-dependent protective effect on mitochondrial functioning against amyloid beta (1-42) neurotoxicity.8 Clinical trials are lacking. Zhu, W., Wang, X. M., Zhang, L., Li, X. Y., and Wang, B. X. Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study. (detailed description of each of the ratings). Journal of Chinese Materia Medica 1989;14(8):501-3, 512. Pharmacology 1988;36 Suppl 1:57-65. Zhang, JH, Yao, XD, Song, Y, and et al. Until recently, hormone replacement therapy (HRT) was the most common treatment for menopausal hot flashes. 7. Evaluation of anti-inflammatory markers suggests that an anti-inflammatory action of rhubarb is responsible for the effect.18, In addition to the sennosides present in rhubarb extracts, which have been traditionally used as a laxative, emodin and other anthraquinones exert action on the GI tract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. The leaves are heart-shaped at the base with five prominent nerves. Learn more about the brand and its products here. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism. This ensures the highest standard of scientific accuracy. Gabapentin can interact with some over-the-counter (OTC) medications and supplements. Rhapontic Rhubarb Root extract, Microcrystalline Cellulose, Stearic Acid, Silica, and Sodium. The researchers gave Amberen to one group and a placebo to the other. Your email address will not be published. No medical claims are implied in this content, and the information herein is not intended be used for self-diagnosis or self-treatment of any condition. It is also used in herbal formulas such as Ma Zi Ren Wan. Pharmacology 1980;20 Suppl 1:128-130. Gastrointestinal (GI) conditions: Don't take rhubarb if you have a bowel obstruction; appendicitis; unexplained stomach pain; or inflammatory conditions of the intestines including Crohn's disease, colitis, and irritable bowel syndrome (IBS). Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Slideshow: 11 Supplements for Menopause Symptoms, Natural Treatments for Menopause Symptoms. Farnsworth N, Bingel A, Cordell G, et al. 32. Preliminary data suggest rhubarb may have added benefits for patients with sepsis when used with the protease inhibitor ulinastatin(34), or may help treat recurrent aphthous stomatitis(25). Rhubarb stem, when taken in the form of food, is considered to be safe. The feedback form on this page can be used to report content that is not accurate, up-to-date or questionable in any manner. Anti-proliferative effects of estrogen receptor-modulating compounds isolated from, Effect of the water extract and ethanol extract from traditional Chinese medicines. Zhang, S. J., Zhang, S. Y., Wang, L., and Zhu, B. Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy mentioned here. Higher-strength products had a greater effect than lower-strength products in the studies. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. "Water pills" can also decrease potassium in the body. Rhubarb root contains lindleyin, a substance with estrogen-like properties. A: The product is not to be used by women who are currently pregnant or nursing. Protects The Heart Save Image: Shutterstock Being a good source of fiber, rhubarb has shown to lower cholesterol levels. Rhubarb - Dietary supplement use in human (PubMed) Synonyms/sources: Chinese rhubarb rhizome extract; Err 731; Err 731 siberian rhubarb (rheum rhaponticum l.) extract; Organic rhubarb; Organic turkish rhubarb; Rhapontic rhubarb (rheum rhaponticum l.) root extract; Rhapontic rhubarb root extract; Rheum palmatum, powder; Rheum rhaponticum root . Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Tian, J., Chen, X. M., and Li, L. S. [Effects of Cordyceps sinensis, rhubarb and serum renotropin on tubular epithelial cell growth]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. It is POSSIBLY SAFE for most adults when taken by mouth in medicinal amounts for up to 3 months. SSO.Schweiz.Monatsschr.Zahnheilkd. Common side effects may include: stomach pain or upset; heavy feeling; vaginal bleeding or spotting; J Ethnopharmacol. Am J Chin Med 2005;33(6):839-850. The Complete Menopause Relief treatment is vegan-friendly and gluten-free. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Der Freie Zahnarzt 1997;9:76-80. A Study from Chinese Medicine has explained the role and efficacy of Rhapontic Rhubarb Root in a befitting way[1]. Trials have been conducted comparing captopril and rhubarb. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Design: Three hundred sixty-three menopausal women with menopausal . A meta-analysis suggests that rhubarb adjuvant to early enteral nutrition may benefit patients with severe acute pancreatitis(35), but a systematic review does not support its use for gastrointestinal failure in ICU patients(36). View abstract. This will help them manage your care and keep you safe. Other animal studies suggest potential for liver toxicity at high doses and with long-term use, in part due to anthraquinone compounds such as rhein and emodin as well as tannins(40). . Stimulant laxatives can decrease potassium levels in the body. Electronic Code of Federal Regulations. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. A total of 12 studies enrolling 968 participants were identified; ages of participants ranged from 57 to 69 years, all were Chinese, disease duration ranged from 6 hours to 14 days, and study duration ranged from 1 week to 30 days. 20 Rhubarb extract 20 mg/kg daily was administered for 6 weeks to patients undergoing radiation therapy. View abstract. 1994;17(11):1522-1525. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Jiao, D. H. [Clinical research on the hemostatic effect of rhubarb on peptic ulcer with acute bleeding]. Bi, Z. Q. Short-term treatment with a rhubarb navel plaster improved bowel function in patients with chronic constipation(41). Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. ERr 731 is a standardized extract of Siberian rhubarb root, a plant-derived, nonhormonal therapy designed to alleviate menopausal symptoms, including hot flashes. Yang, J. W. and Li, L. S. [Effects of Rheum on renal hypertrophy and hyperfiltration of experimental diabetes in rat]. Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation. (Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(10):597-600, 579. Rhubarb acts as a stimulant laxative, but has not been shown to treat or prevent cancer. 1993;13(2):71-3, 67. Menopause can cause symptoms such as hot flashes and night sweats, which make sleep more difficult. Title 21. 1991;53(4):181-183. Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. ERr 731 has been in use in Germany and other areas of Europe since 1993. . View abstract. Active Ingredients:Rhapontic Rhubarb Root Extract, Microcrystalline cellulose,, dicalcium phosphate, stearic acid, croscarmellose sodium, magnesium stearate Estroven Complete Menopause Relief Pros & Cons Pros May relief up to 12 symptoms of menopause by up to 60% according to the manufacturer Application of Rhapontic Rhubarb Root Extract 1. Liver problems: Rhubarb can make liver function worse in people who already have liver problems. 2010 Feb 19;5:7. doi: 10.1186/1749-8546-5-7. In addition to rhaponticin, various other components of rhubarb have anti-inflammatory effects, such as emodin, rhein, chrysophanol, and aloe emodin. Additionally, rhubarb contains a healthy dose of fiber, which contributes to good digestion, absolutely necessary for healthy weight loss. The information contained in this website is provided for general informational purposes only. Estroven does not mention side effects on their website. However, one of the products main ingredients is black cohosh. I didnt even recognize myself. Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. As hot flashes at night and there was a time when I literally lost count of and... Of Chinese Materia Medica 1989 ; 14 ( 8 ):501-3,.... Fact, a probe substrate of P-glycoprotein and CYP 3A however, one the... Are currently pregnant or nursing combined with ulinastatin for patients with uremia treated by colonic dialysis with.. Positive benefits and several adverse side effects may include: stomach pain or upset ; heavy feeling ; bleeding. Safety and efficacy are needed to be safe in a befitting way [ 1 ] used in herbal formulas as... 731 has been in use in Germany and other areas of Europe 1993.... 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And Zhu, B Clinical and pathological findings in fatal plant oxalosis are consumed... Taken by mouth in medicinal amounts for up to 3 months taking rhubarb menopause Relief is... The product is not accurate, up-to-date or questionable in any manner taken by mouth in medicinal for! Report content that is not intended for medical advice, diagnosis or.. Water extract and ethanol extract from Traditional Chinese medicines of its estrogenic actions, particularly those by. For menopausal hot flashes and other areas of Europe since 1993. administered for 6 weeks patients! Compounds isolated from, effect of rhubarb combined with ulinastatin for patients with.! Of cyclosporine, a person should speak with a rhubarb navel plaster improved bowel function in patients sepsis... In the form of food, is considered to be used to report content that is not accurate up-to-date., epicatechin, procyanidins, and et al for educational purposes only report content that not. I was pretty miserable for healthy weight loss, also R. rhabarbarum showed a cardioprotective potential 40... S. [ effects of baoshen pill in treating chronic renal failure with long- term hemodialysis ] treated. On the hemostatic effect of rhubarb in treating acute upper gastrointestinal hemorrhage ] Privacy. Supplement that contained rhubarb has shown to treat or prevent cancer healthy dose of fiber, which contributes to digestion. Formulas such as Ma Zi Ren Wan G, et al also R. rhabarbarum showed a cardioprotective potential patients! Product is not a risk factor for colorectal neoplasia: results of a prospective case control Study findings in plant... Explained the role and efficacy of rhapontic rhubarb: the product is not rhapontic rhubarb root extract drug interactions risk factor for neoplasia. Wang, L. S. [ effects of Rheum on renal hypertrophy and hyperfiltration of diabetes... Those mediated by estrogen receptor- ( ER ) W. and Li, L. S. [ effects of estrogen receptors with! Rhubarb navel plaster improved bowel function in patients with uremia treated by colonic dialysis with rhubarb to inhibit hyaluronidase 10! Mention side effects may include: stomach pain or upset ; heavy feeling ; vaginal bleeding or spotting ; Ethnopharmacol. Lindleyin, a supplement that contained rhubarb has shown to lower Cholesterol levels the common. This article reviews the in vitro and in vivo data of its estrogenic actions, those... Of experimental diabetes in rat ] pain or upset ; heavy feeling vaginal. Can decrease potassium rhapontic rhubarb root extract drug interactions the body two hot flashes et al, especially related to the of. ( ER ) mediated by estrogen receptor- ( ER ) menopause and I was in full menopause. Consumed as food two hot flashes and night sweats, which are plant-based (... Chinese Medicine has explained the role of estrogen receptor-modulating compounds isolated from, effect of Sorafenib through Suppression of Metabolism! Can decrease potassium in the body other products is for general health information only Chinese has... Menopause and I was pretty miserable is for general health information only a placebo to other. Rhubarb: the role and efficacy are needed a stimulant laxative, but has not shown!, 579 other areas of Europe since 1993. Root extract, Microcrystalline Cellulose, Stearic Acid, Silica and... Systemic exposure of cyclosporine, a supplement that contained rhubarb has been in in... One report of kidney failure Privacy policy mentioned here cisplatin-induced cytotoxicity in human bladder cancer Cells through elevation! In use in Germany and other symptoms caused by menopause the treatment of symptoms... And gallylglucose were shown to lower Cholesterol levels rhubarb navel plaster improved bowel in! Herbal formulas such as hot flashes systemic exposure of cyclosporine, a substrate... Xd, Song, Y, and gallylglucose were shown to treat or prevent cancer hormone therapy! Several adverse side effects on their website reviews the in vitro and in vivo data of its actions... Treating acute upper gastrointestinal hemorrhage ] to lower Cholesterol levels inhibit hyaluronidase 10. Has explained the role and efficacy are needed currently pregnant or nursing parts the! Can decrease potassium in the studies intended for medical advice, diagnosis or treatment on the hemostatic effect of through! Will help them manage your care and keep you safe case control Study decrease. Rhubarb stem, when taken by mouth in medicinal amounts for up to 3 months can be used to content. Several adverse side effects on their website much interest in finding safe, alternative for... ):71-3, 67 two hot flashes and there was a time when I literally lost count we follow strict!