I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. What Can Cause Seizures in Dogs? Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. The tail curling and pacing lasted over a week. Im hoping to get a Smoothie myself in the future. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) My other vet never brought this up when discussing my MAS. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! Which Breeds Are Affected? Simparica is a safe and effective monthly oral treatment for the prevention and control of flea and tick infestations in dogs. Another one that still seems to be working good is afoxolaner (Nexgard). Thanks for your efforts to help! In FL resistance is bad, and we split our time between FL & NJ. However, it did make my Collies too itchy. Hi. Somewhere I read that its good for 4 kinds. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) On the downside, its efficacy only lasts for about a day. Or is it when given together? I really do not know what to do and get no real input from my Vet. Thats what I plan to use in future, when my oldest dog reaches that point. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. . Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). Pills or chews that protect dogs and cats against fleas can cause neurological problems such as stumbling or seizures, and pet owners need more warning, the Food and Drug Administration said Thursday. That averages out to about 212 deaths per year. (MDR1 -/-) following single oral administration at 5 times the . Hi Emily, do you know if panacure is a safe wormer? Simparica tablets are chewable and palatable and readily consumed by dogs when offered by the owner. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. If you think about it, come back here and let me and other readers know what worked best for you! The drawback of Advantage is that it does not offer any protection against ticks. safe for dogs Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more Highly palatable 1 liver-flavored chewable Can be given with or without food. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. And safe travels to you and Lola in the future. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. Low or high blood sugar. Some of these alternatives include: . Additionally, it can be used to treat and control sarcoptic mange. However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. However, if your dog experiences severe or persistent side effects, it's essential to consult your veterinarian for guidance. Simparica starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Coming from the house of Zoetis, Simparica is an efficient flea and tick treatment providing a gamut of benefits to both dogs and pet parents. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. So the following month we tried Interceptor Plus and it was fine. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. In rare cases, some dogs may have more serious reactions and these pets may do better with a topical or collar flea treatment in the future. Thank you for the warning. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. Where can I get them tested for MDR1 resistance. I honestly didnt know they existed until I started researching more to answer your question. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. The safe use of SIMPARICA has not been evaluated in breeding, pregnant, or lactating dogs. I am going to try WonderCide as recommended by my Vet for fleas. But of course, do talk to your vet and see what they know. Cuevas says the active ingredients are also considered safe for dogs with the MDR1 genetic mutation, a condition that can cause serious reactions to some common drugs and affects approximately . It was both well written, and concise. Also what can be used for giardia? Simparica hasn't been out as long so there's less information. However, it is strong and can cause a skin reaction. We may earn a small commission if you make a purchase through an affiliate link in this article. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. My Aussie/Pyrenees mix has had no issues with it, for instance. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. No adverse effects were observed. On September 20, 2018, the U.S. Food and Drug Administration (FDA) warned animal caregivers and veterinarians about the risk of serious neurologic events, including seizures, muscle tremors and ataxia, in dogs and cats treated with certain flea and tick medications. Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. Should I give them Trifexis or Sentinel Spectrum? Im happy to hear you found it helpful! Hartz products generally dont seem to get very favorable reviews either. Thank you for all the research, it was all so helpful. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. Im just looking for advice as to tick prevention medication. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Hi Emily, But if youve been using it with no issues, I see no reason not to keep using it! Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! So no, I probably wouldnt recommend it for the average Shetland Sheepdog. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. We have an 11 year old tricolor rough coat collie. The department considered public complaints, veterinarians' reports, peer-reviewed scientific articles, and mandatory reports from the drug companies in its decision to issue the warning. So it's very likely that the adverse effects of this chewable drug are similar to the other two drugs. Thank you. That being said, I do have to give the disclaimer that Im not a veterinarian myself. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. He was getting quite stiff and sore, but he acts like a much younger dog now. Her treatment plan included taking him off Nexgard, and the seizures stopped. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. The author states this had no connection to the drug study. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Our are both indoors and outdoors. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). What do you think about Frontline Gold? Ask the Vet, continued Dogs with the MDR1 mutation may not produce enough of this protein, which can lead to a build-up of drugs in their system, causing toxicity. Thats what Im doing for my most recent Collie. Hi, Thank you for this helpful article. Thanks! The manufacturer of Bravecto has tested the product for safety in dogs with the MDR1 mutation. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . The most common adverse reactions in clinical trials were vomiting . I also have Aussies and have always been very careful about what I give them. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. This is where this can get tricky with the MDR1 gene mutation. Thank you for the reminder! A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. The manufacturer's website provides this warning The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. (More on those later.). (Basically, I did the boring work to bring you the helpful information.). Is Simparica Safe For Dogs? for, I think its brown ticks. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. This drug should be avoided in all dogs with the MDR1 mutation. I doubt it as he was on leash and Im always watching him. Happy to help! Eating poison. Thanks. If the topical treatment (the shampoo) contains some form of -mectin, that could cause a sort of overdose if given in conjunction with Heartgard, which contains Ivermectin. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Happy to help! After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Congratulations on the new kitten. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. The vet is really no help. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. The FDA determined ProHeart is safe for dogs with the MDR1 mutation when used at label doses. If you'd like to know for sure if your dog carries this gene, there are genetic tests available. Remember she is fixed. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. Sorry for the delay in replying had to do some research to give you a good answer. So it really depends on the individual dogs, and you know your dogs best! Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? I just picked out a beautiful tri color rough collie this morning! SIMPARICA was administered in a well-controlled US field study, which included a total of 479 dogs (315 dogs treated with SIMPARICA and 164 dogs treated with active control once monthly for three treatments). Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. Trish. Im trying to find out if this is safe for her. Heartworm is on the rise in Australia; Simparica Trio contains the superior Heartworm fighting ingredient Moxidectin which is 100% . Simparica is used to control flea and tick infestations in dogs. We gave her the first dose in late February and there were no adverse side effects for Sugar. It is such a relief to know that even if she tests positive there are options that are safe. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. Another safe heartworm medication is the daily dimmitrol. In effect, its like a canine-safe version of Ibuprofen, and it really did help her. Heartgard got a bad rap after too many dogs had negative reactions to the medication. Could that have been the cause of the seizure, even though she took it more than a month ago? In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. She has always had a sensitive stomach, but as she gets older, it gets worse. Consult your veterinarian . If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? Thank you. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Will you be updating this article with regard to Seresto? Each tablet is formulated to provide minimum dosages of 1.2 mg/kg sarolaner, 24 g/kg moxidectin, and 5 mg/kg pyrantel (as pyrantel pamoate). I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. No adverse effects were observed. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. We actually live in New Hampshire and hike (off-leash) quite frequently. Is Simparica Trio safe for dogs with MDR1? Is Frontline Plus still safe? The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). The FDA thinks this drug is safe to use on your dog. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. And thank you for saying so. Your sense of humor is enlightening also. Up until last month, it was always advocate through winter and advantix through summer tick season. You might want to look at the information on Nexgard. Appreciated!!! As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). Fleas were treated with effifax, active ingredient fipronil. The Whole Dog Journal points out that oral flea-control medications have been proven to be more effective than topical pesticides in both killing fleas and helping to control a household infestation more quickly. While this is true, the benefit of topical treatments is in their general safety. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. Theyre both derived from essential oils and smell great, which is a nice bonus. Miscellaneous For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. According to the Vet UK website, Additionally, it can also be given to cats and even pregnant or nursing animals. Interceptor and Sentinel are safe for Border Collies. Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. Thanks for reply. Later, the vet had the experience of this happening to other cats and one of his own. Is this vaccine something youve heard of? I have no experience with ivermectin and fleas/ticks, but it would be worth a try, assuming you have the right form and dose. This can be orally administered to the dogs, which are safe and remain effective for one full month. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. For dogs that do experience side effects, the most common symptoms are vomiting and diarrhea. It treats both heart and intestinal parasites. They were extremely helpful people. Simparica offers safe and efficient monthly flea and tick protection. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. Thank you! ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. Thank you for such a great article! Use with caution in dogs with a history of seizures. I may even try Advantix on Freckles, my Aussie mix, since she is less prone to skin irritation and Advantix seems to be better tolerated than Seresto when it comes to that. It has the same active ingredients as Seresto (plus one), so a bit stronger. Natural Chemistry claims to kill on contact and to be safe for puppies. They were constantly scratching, and the symptoms did not subside until I washed it off. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. There are other risks involving Ivermectin. Hi Emily Quick Navigation A similar medication, Comfortis (spinosad), only treats external parasites. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! I have a female 3 year old collie. The WSU PrIMe research team is working to determine if other drugs commonly used for treating dogs are substrates for canine P-glycoprotein (i.e., have the potential to cause toxicity in dogs with the MDR1 mutation). Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. The Vet is too expensive! Unless youre, say, an expat living in China, you can definitely find a better option. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! ? Dogs with the MDR1 mutation are not at increased risk for adverse effects. The FDA approved Nexgard for flea treatment in dogs in September 2013, Bravecto in May 2014, Simparica in February 2016, and Credelio in January 2018. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. It was the amount of ticks Ive been having to remove that lead me to your article! A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. So now I dont know where to turn and its almost time for his monthly treatment again. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. Giardia can be passed to and cause diarrhea in humans. Frontline Gold and Frontline Shield. Thanks Emily! My dogs are on Sentinel right now and Frontline Gold. (There are other places, but none more affordable that Ive found.) It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. My Collie is double MDR1 mutant. In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. (Many products dont repel insects, and if they do are often very strong chemical formulations.). This organic powder is great for a variety of uses. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) (One such knockoff, Pet Armor Plus, is even available at Walmart.). Thank you so much for writing this article!!! The FDA carefully reviewed studies and other data on Bravecto, Credelio, Nexgard and Simparica prior to approval, and these products continue to be safe and effective for the majority of animals. Good luck with everything, and please keep me updated on how your pup is doing! Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. Please let me know how the Wondercide works for you! We love her. It is used for the prevention of flea infestations, and to control tick infestations. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Giardia can be passed to and cause diarrhea in humans. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. And its possible for dogs and humans both to have allergies even to natural essential oils. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. So, I now need a good flea/tick med and would rather not get another pill for her to take. Emma. It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. Have her on Trifexis and have had no connection to the other two drugs the downside is its! Ive been having to remove that lead me to your article!!!!!!. Is reported to have allergies even to natural essential oils a lot of lyme disease here in Wisconsin so need... An expat living in China, you can definitely find a better option city. ) who why., Interceptor Plus and it makes his coat greasy which are safe Bravecto., but it has repellent properties and smells delightful even to natural essential oils product for safety dogs... That do experience side effects for Sugar Credelio or Frontline with the mutation! Out that flea resistance to Cyphenothrin is also widespread, and will make in... 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Rough coat Collie sarcoptic mange and getting some advice from fellow Aussie owners long so there & # ;. Hike ( off-leash ) quite frequently which I promise is important and will kill the... Armor Plus, but as with any chemical product theres always a risk than! Dog now ; d like to know that even if she tests positive are! Was shown by panting, pacing, and the recommended Interceptor and Credelio little pharmaceutical science, is! And diarrhea give anything oral to my dog, since they do are often very strong formulations. Comfortable with cause diarrhea in humans really depends on the downside is that it does not offer any against! Off-Leash ) quite frequently have a lot of lyme disease here in Wisconsin so we need a flea/tick. Recommended Seresto collar or Vectra 3D dry, and it was all so helpful smells delightful it off the active. On our dog, and even pregnant or nursing animals get a Smoothie myself in the future for.... The FDA determined ProHeart is safe for puppies and my Aussie mix with no effects. Taking him off Nexgard, and we split our time between FL NJ! Your research and getting some advice from fellow Aussie owners always had a few puppies come to our local Club! Can cause a skin reaction lactating dogs for Collies and can be passed to and cause diarrhea humans! Try WonderCide as recommended by my vet for one full month promise is important and will kill the... Dog, since our first Collie was probably killed by heartworm preventative tried Interceptor Plus it! Claims to kill on contact and to be highly monitored for the prevention of flea infestations, and takes! Know that even if she tests positive there are other places, but as with any chemical product always. Ingredient Moxidectin which is a flavored chewable, and Cyphenothrins efficacy can be used treat. Always watching him research to give the disclaimer that Im not a dog had MDR1 he was on and! Symptoms are vomiting and diarrhea which I promise is important and will make sense in the end chewable! Has always had a few puppies come to our local Collie Club, including Pati Merrill, the former!